Can a genetic test result change?

An individual's DNA sequence does not change over time. However, with every Helix test performed, genetic variants of uncertain significance (VUS) are identified. A VUS means that a genetic variant was found but its impact on disease is uncertain. Further research and evidence are needed to determine the exact impact of the variant on health. VUS's are not returned through participation in the Helix Research Network. Therefore, results returned to participants are either labeled as "positive" (meaning a pathogenic or likely pathogenic variant was found) or "negative" (meaning that no pathogenic or likely pathogenic variants were found). These labels can change if new information leads Helix to reclassify a VUS. In such situations, a participant's test result interpretation may change, for example, from negative to positive (or rarely, from positive to negative). Variant reclassifications occur as a result of ongoing research, improved understanding of genetic data and advances in the field of genetics. When variants are reclassified, Helix will provide detailed information regarding the revised reclassification, including specific reasons behind the change and potential medical implications.